Marie Ludvíková
Charles University in Prague
CancerPathologyOncologymicroRNAThyroid peroxidaseImmunohistochemistryBiopsyFine-needle aspirationHead and neck squamous-cell carcinomaCarcinomaFollicular cellCytokeratinMalignancyThyroid cancerDifferential diagnosisAtypiaCancer researchThyroidMedicineBiology
51Publications
15H-index
620Citations
Publications 50
Newest
#1Ivana KholováH-Index: 9
#2David Kalfert (First Faculty of Medicine, Charles University in Prague)H-Index: 8
Last. Marie Ludvíková (Charles University in Prague)H-Index: 15
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Follicular epithelial dysplasia (FED) is described as Hashimoto thyroiditis-related atypia and is thought to be a possible precancerous lesion. Dysplasia as an interface between normal state and carcinoma is described in a wide range of diseases and carcinogenesis chains. On the other hand, inflammation-related atypia and cancerogenesis is also widely studied. In this study, we retrospectively analyzed 91 specimens of thyroid gland surgical resections with FED during a 10-year-period at the univ...
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#1Mikk Abram (UTA: University of Tampere)H-Index: 1
#2Roope Huhtamella (UTA: University of Tampere)H-Index: 1
Last. Ivana Kholová (UTA: University of Tampere)H-Index: 9
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INTRODUCTION Thyroid cytology is a widely accepted tool in the clinical triaging of nodular lesions. Cell blocks (CBs) can help in the diagnosis of atypical lesions, namely, thyroid Bethesda category of Atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS). METHODS In a series of 224 AUS/FLUS thyroid samples with CB, we studied CB cellularity and feasibility of 3 immunohistochemical markers (cytokeratin 19 [CK19], HBME-1, and galectin-3) apart and in combi...
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#1Jarkko LintusaariH-Index: 1
#2Eini VesaniemiH-Index: 1
Last. Ivana KholováH-Index: 9
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IgG4-positive plasma cells in Hashimoto thyroiditis: IgG4-related disease or inflammation-related IgG4-positivity? Despite the interest of researchers in IgG4-related disease (IgG4-RD), many questions still remain unanswered regarding the thyroid gland. We aimed to clarify the relationship between IgG4-positive plasma cells and the histopathological pattern in the Hashimoto thyroiditis (HT) in a Finnish series. HT specimens (n=280) were retrieved from the Department of Pathology, Fimlab Laborato...
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#1Lucie Dostalova (First Faculty of Medicine, Charles University in Prague)H-Index: 2
#2David Kalfert (First Faculty of Medicine, Charles University in Prague)H-Index: 8
Last. Jan Plzak (First Faculty of Medicine, Charles University in Prague)H-Index: 19
view all 11 authors...
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#1David Kalfert (Charles University in Prague)H-Index: 8
#2Marie Ludvíková (Charles University in Prague)H-Index: 15
Last. Ivana KholováH-Index: 9
view all 6 authors...
MiR-34a belongs to the class of small non-coding regulatory RNAs and functions as a tumor suppressor. Under physiological conditions, miR-34a has an inhibitory effect on all processes related to cell proliferation by targeting many proto-oncogenes and silencing them on the post-transcriptional level. However, deregulation of miR-34a was shown to play important roles in tumorigenesis and processes associated with cancer progression, such as tumor-associated epithelial-mesenchymal transition, inva...
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#1Lucie Dostalova (First Faculty of Medicine, Charles University in Prague)H-Index: 2
#1Lucie Dostalova (First Faculty of Medicine, Charles University in Prague)H-Index: 1
Last. Jan Plzak (First Faculty of Medicine, Charles University in Prague)H-Index: 19
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The treatment strategy of parotid gland tumours depends mainly on the histopathological type of the lesion. Fine-needle aspiration biopsy (FNAB) is recommended in preoperative diagnostics. The aim of the study was to evaluate the FNAB standing in the diagnostic algorithm of parotid gland lesions and to correlate FNAB results in relation to the definitive histopathological diagnosis. The retrospective analyses of 651 examined and consequently surgically treated parotid gland lesions at the Depart...
6 CitationsSource
#1David Kalfert (First Faculty of Medicine, Charles University in Prague)H-Index: 8
#2Marie Ludvíková (Charles University in Prague)H-Index: 15
Last. Jan Plzak (First Faculty of Medicine, Charles University in Prague)H-Index: 19
view all 6 authors...
The differential diagnosis of well-differentiated tumors of follicular cell origin remains the most problematic task in thyroid pathology. Specific morphologic criteria (capsular and/or vascular invasion, nuclear characteristics) are crucial in the diagnosis of these neoplasms. However, the assessment of malignant features is inconclusive in some cases. Moreover, oncocytic thyroid tumors remain controversial in a respect to their pathobiology, behavior and management. Therefore, the useful diagn...
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#1David Kalfert (First Faculty of Medicine, Charles University in Prague)H-Index: 8
#2Jaroslav Ludvik (Charles University in Prague)H-Index: 3
Last. Marie Ludvíková (Charles University in Prague)H-Index: 15
view all 9 authors...
BACKGROUND/AIM: The aim of this study was to analyze the pretreatment cytokeratin serum levels in head and neck squamous cell carcinoma (HNSCC) by three assays in relation to selected clinicopathological characteristics in an effort to find diagnostic/prognostic biomarkers for HNSCC and determine the best assay. PATIENTS AND METHODS: In total, 46 patients with HNSCC with different subsite (oropharyngeal-21 cases, hypopharyngeal-4 and laryngeal-21) were included in this prospective study. MonoTot...
1 CitationsSource
#1Marie LudvíkováH-Index: 15
#2Ivana KholováH-Index: 9
Last. David KalfeřtH-Index: 3
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Background Central to neoplastic transformation and tumor progression is alteration of the signaling pathways that control cell proliferation and apoptosis. The key mechanisms for this neoplastic process are genetic changes (mutations of cancer-related genes) and recently identified epigenetic changes that involve DNA methylation, chromatin remodeling (which has a profound effect on the control of gene expression), and noncoding, regulatory RNA (notably, microRNA - miRNA). MiRNAs control express...
1 CitationsSource
#1Marie Ludvíková (Charles University in Prague)H-Index: 15
#2Ivana KholováH-Index: 9
Last. David Kalfeřt (Charles University in Prague)H-Index: 3
view all 3 authors...
Tyreoidalni nadorova medicina vstoupila do nove, molekularni ery, kdy detailni poznani vsech molekularnich aspektů může přispět ke zlepseni diagnostiky a prognozovani nadorů stitne žlazy i k rozvoji nových lecebných strategii. Geneticke a epigeneticke změny vsak tvoři nedilný komplex podilejici se na aktivaci signalnich drah stěžejnich pro vznik nadorů z folikularnich buněk. Významnou roli v tomto procesu hraji mikroRNA, jejichž profilovani a srovnavani výsledků jednotlivých studii je vsak spoje...