Ned D. Heindel
Lehigh University
AdductMolecular biologyMedicinal chemistryOrganic chemistryEnzymeChemistryCombinatorial chemistryInflammationKeratinocyteAcetylenedicarboxylateRing (chemistry)NitroSulfur mustardArylPsoralenUltraviolet lightGlutathioneMonoclonal antibodyBiochemistryStereochemistryMedicineBiologyPharmacology
175Publications
20H-index
2,381Citations
Publications 167
Newest
#1Christophe Guillon (Lehigh University)H-Index: 8
#2Anna M. Vetrano (RU: Rutgers University)H-Index: 15
Last. Jeffrey D. Laskin (RU: Rutgers University)H-Index: 1
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Abstract A set of 4-(R2-imino)-3-mercapto-5-(R1)-4H-1,2,4-triazoles derivatives were synthesized, characterized and evaluated for their ability to inhibit nitric oxide (NO) production in PAM212 mouse keratinocytes, which led to the discovery and the subsequent evaluation of their growth inhibitory cytotoxic potency toward that same mouse cell line together with a number of human cells lines (PC3, HT-29 and HeLa). Some limited SAR could be established for both NO production inhibition potency and...
2 CitationsSource
#1Gabriella Wahler (RU: Rutgers University)H-Index: 1
#2Diane E. Heck (NYMC: New York Medical College)H-Index: 4
Last. Laurie B. Joseph (RU: Rutgers University)H-Index: 12
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Abstract Nitrogen mustard (NM) is a highly reactive bifunctional alkylating agent that induces inflammation, edema and blistering in skin. An important mechanism mediating the action of NM and related mustards is oxidative stress. In these studies a modified murine patch-test model was used to analyze DNA damage and the antioxidant/stress response following NM exposure in isolated epidermis. NM (20 μmol) was applied to glass microfiber filters affixed to a shaved dorsal region of skin of CD-1 mi...
1 CitationsSource
#1Christophe Guillon (Lehigh University)H-Index: 8
#2Yi Hua Jan (RU: Rutgers University)H-Index: 3
Last. Ned D. Heindel (Lehigh University)H-Index: 20
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Abstract Seventy-one 7-oxycoumarins, 66 synthesized and 5 commercially sourced, were tested for their ability to inhibit growth in murine PAM212 keratinocytes. Forty-nine compounds from the library demonstrated light-induced lethality. None was toxic in the absence of UVA light. Structure-activity correlations indicate that the ability of the compounds to inhibit cell growth was dependent not only on their physiochemical characteristics, but also on their ability to absorb UVA light. Relative li...
Source
#1Christophe Guillon (Lehigh University)H-Index: 8
#2Yi-Hua Jan (RU: Rutgers University)H-Index: 8
Last. Ned D. Heindel (Lehigh University)H-Index: 20
view all 7 authors...
Abstract Linear furocoumarins, also known as psoralens, are clinically useful photo-activated pharmaceuticals employed to address hyperproliferative skin diseases. Seven diverse cytotoxic pharmacophores have been synthetically attached to 8-methoxypsoralen via a 5-amino functionality. The resulting unique set of compounds was evaluated for dark and light toxicity against PAM212 keratinocytes in culture.
4 CitationsSource
#1Laurie B. Joseph (RU: Rutgers University)H-Index: 12
#2Gabriella M. Composto (RU: Rutgers University)H-Index: 5
Last. Diane E. Heck (NYMC: New York Medical College)H-Index: 38
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Abstract Sulfur mustard (SM, bis(2-chloroethyl sulfide) is a potent vesicating agent known to cause skin inflammation, necrosis and blistering. Evidence suggests that inflammatory cells and mediators that they generate are important in the pathogenic responses to SM. In the present studies we investigated the role of mast cells in SM-induced skin injury using a murine vapor cup exposure model. Mast cells, identified by toluidine blue staining, were localized in the dermis, adjacent to dermal app...
8 CitationsSource
#1Christophe Guillon (Lehigh University)H-Index: 8
#2Yi-Hua Jan (RU: Rutgers University)H-Index: 8
Last. Ned D. Heindel (Lehigh University)H-Index: 20
view all 9 authors...
The natural product 8-methoxypsoralen (methoxsalen or 8-MOP) in combination with long wavelength ultraviolet light (UVA, 320-400 nm), also referred to as PUVA therapy, is used for the treatment of cutaneous proliferative disorders including psoriasis, vitiligo and mycosis fungoides. The use of 8-MOP (3) is limited by its poor water solubility and there remains a need to develop more water-soluble psoralens to enhance bioavailability following oral administration of the drug. In the present studi...
#1Jeffrey D. Laskin (RU: Rutgers University)H-Index: 69
#2Yi-Hua Jan (RU: Rutgers University)H-Index: 8
Last. Ned D. Heindel (Lehigh University)H-Index: 20
view all 7 authors...
: Photosensitizers are used in the treatment of epidermal proliferation and differentiation disorders such as psoriasis and vitiligo. In these studies, a ring-expanded carbon homolog of the linear psoralen (furo[3,2-g]benzopyran-7-one) class of photosensitizers, 4,10-dimethyl-2H,8H-benzo[1,2-b:5,4-b']dipyran-2-one (NDH2476), was synthesized and analyzed for biological activity. Following activation by ultraviolet light (UVA, 320-400 nm), NDH2476 was found to be a potent inhibitor of keratinocyte...
2 CitationsSource
#1Ned D. Heindel (Lehigh University)H-Index: 20
Last. James J. Bohning (Lehigh University)
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Source
#1Atta-ur-RahmanH-Index: 60
#2M. Iqbal ChoudharyH-Index: 63
Last. Billy PickH-Index: 1
view all 82 authors...
3 Citations
#1Marion K. Gordon (RU: Rutgers University)H-Index: 21
#2Andrea DeSantis-Rodrigues (RU: Rutgers University)H-Index: 2
Last. Donald R. Gerecke (RU: Rutgers University)H-Index: 18
view all 8 authors...
1 Citations