Oscar Miranda-Dominguez
University of Minnesota
Motion (physics)Internal medicineEndocrinologyMental healthCognitive developmentArtificial intelligencePsychologyNeuroscienceCognitionCognitive psychologyFunctional imagingCortex (anatomy)Motor cortexMacaqueAmygdalaFunctional magnetic resonance imagingParkinson's diseasePrefrontal cortexPreferenceFunctional connectivityFunctional brainComputer visionAffect (psychology)Computer scienceAnxietyNeuroimagingResting state fMRIMedicineBiology
Publications 32
#1Melanie Pincus (Yerkes National Primate Research Center)H-Index: 3
#2Jodi S Godfrey (Yerkes National Primate Research Center)
Last. Clare Kelly (Trinity College, Dublin)H-Index: 50
view all 9 authors...
Abstract In females, pubertal onset appears to signal the opening of a window of increased vulnerability to the effects of stress on neurobehavioral development. What is the impact of pubertal timing on this process? We assessed the effects of pubertal timing and stress on behavior and amygdala functional connectivity (FC) in adolescent female macaques, whose social hierarchy provides an ethologically valid model of chronic psychosocial stress. Monkeys experienced puberty spontaneously (n=34) or...
#1Carla Silva-Batista (USP: University of São Paulo)H-Index: 10
#2Anjanibhargavi Ragothaman (OHSU: Oregon Health & Science University)H-Index: 5
Last. Oscar Miranda DominguezH-Index: 1
view all 10 authors...
We previously showed that dual-task cost (DTC) on gait speed in people with Parkinson's disease (PD) improved after 6 weeks of the Agility Boot Camp with Cognitive Challenge (ABC-C) exercise program. Since deficits in dual-task gait speed are associated with freezing of gait and gray matter atrophy, here we performed preplanned secondary analyses to answer two questions: (a) Do people with PD who are freezers present similar improvements compared to nonfreezers in DTC on gait speed with ABC-C? (...
#1Oscar Miranda-Dominguez (OHSU: Oregon Health & Science University)H-Index: 15
Last. Fay B. Horak (OHSU: Oregon Health & Science University)H-Index: 104
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Abstract Freezing of gait (FoG) is a brief, episodic absence or marked reduction of forward progression of the feet, despite the intention to walk, that is common in people with Parkinson’s disease (PD). We hypothesized that not only motor, but higher level cognitive and attention areas may be impaired in freezers. In this study, we aimed to characterize differences in cortical and subcortical functional connectivity specific to FoG. We examined resting state neuroimaging and objective measures ...
2 CitationsSource
#1Scott Marek (WashU: Washington University in St. Louis)H-Index: 13
#2Brenden Tervo-Clemmens (University of Pittsburgh)H-Index: 10
Last. Nico U.F. Dosenbach (WashU: Washington University in St. Louis)H-Index: 36
view all 37 authors...
Magnetic resonance imaging (MRI) continues to drive many important neuroscientific advances. However, progress in uncovering reproducible associations between individual differences in brain structure/function and behavioral phenotypes (e.g., cognition, mental health) may have been undermined by typical neuroimaging sample sizes (median N=25)1,2. Leveraging the Adolescent Brain Cognitive Development (ABCD) Study3 (N=11,878), we estimated the effect sizes and reproducibility of these brain wide a...
52 CitationsSource
#1Caterina Gratton (NU: Northwestern University)H-Index: 25
#2Ally Dworetsky (WashU: Washington University in St. Louis)H-Index: 3
Last. Meghan C. Campbell (WashU: Washington University in St. Louis)H-Index: 20
view all 18 authors...
Abstract Denoising fMRI data requires assessment of frame-to-frame head motion and removal of the biases motion introduces. This is usually done through analysis of the parameters calculated during retrospective head motion correction (i.e., ‘motion’ parameters). However, it is increasingly recognized that respiration introduces factitious head motion via perturbations of the main (B0) field. This effect appears as higher-frequency fluctuations in the motion parameters (> 0.1 Hz, here referred t...
16 CitationsSource
#1Jodi R. Godfrey (Yerkes National Primate Research Center)H-Index: 7
#2Melanie Pincus (Yerkes National Primate Research Center)H-Index: 3
Last. Vasiliki Michopoulos (Emory University)H-Index: 26
view all 12 authors...
Abstract Alterations in dopamine (DA) signaling and reductions in functional connectivity (FC; a measure of temporal correlations of activity between different brain regions) within dopaminergic reward pathways are implicated in the etiology of psychopathology and have been associated with increased concentrations of inflammatory markers, including C-reactive protein. Peripheral and central inflammatory cytokines that have been shown to disrupt DA signaling and corticostriatal FC are associated ...
3 CitationsSource
#1Michaela Cordova (OHSU: Oregon Health & Science University)H-Index: 6
#2Kiryl Shada (Boston Children's Hospital)H-Index: 1
Last. Eric Feczko (OHSU: Oregon Health & Science University)H-Index: 23
view all 13 authors...
Abstract Background : Those with autism spectrum disorder (ASD) and/or attention-deficit-hyperactivity disorder (ADHD) exhibit symptoms of hyperactivity and inattention, causing significant hardships for families and society. A potential mechanism involved in these conditions is atypical executive function (EF). Inconsistent findings highlight that EF features may be shared or distinct across ADHD and ASD. With ADHD and ASD each also being heterogeneous, we hypothesized that there may be nested ...
4 CitationsSource
#1Julian S.B. Ramirez (OHSU: Oregon Health & Science University)H-Index: 5
#2Alice M. Graham (OHSU: Oregon Health & Science University)H-Index: 17
Last. Damien A. FairH-Index: 63
view all 18 authors...
Human and animal cross-sectional studies have shown that maternal levels of the inflammatory cytokine interleukin-6 (IL-6) may compromise brain phenotypes assessed at single time points. However, how maternal IL-6 associates with the trajectory of brain development remains unclear. We investigated whether maternal IL-6 levels during pregnancy relate to offspring amygdala volume development and anxiety-like behavior in Japanese macaques. Magnetic resonance imaging (MRI) was administered to 39 Jap...
5 CitationsSource
#1Damien A. Fair (OHSU: Oregon Health & Science University)H-Index: 63
#2Oscar Miranda-Dominguez (OHSU: Oregon Health & Science University)H-Index: 15
Last. Nico U.F. DosenbachH-Index: 36
view all 28 authors...
Abstract Head motion represents one of the greatest technical obstacles in magnetic resonance imaging (MRI) of the human brain. Accurate detection of artifacts induced by head motion requires precise estimation of movement. However, head motion estimates may be corrupted by artifacts due to magnetic main field fluctuations generated by body motion. In the current report, we examine head motion estimation in multiband resting state functional connectivity MRI (rs-fcMRI) data from the Adolescent B...
38 CitationsSource