David J. Whellan
Thomas Jefferson University
Quality of lifeInternal medicineSurgeryCardiologyRandomized controlled trialIntensive care medicinePhysical therapyEmergency medicineHazard ratioAction (philosophy)Heart failureAcute decompensated heart failureHeart diseasePopulationIn patientConfidence intervalProportional hazards modelClinical trialMedicineEjection fraction
336Publications
66H-index
14.3kCitations
Publications 336
Newest
#1Evan Murray (Duke University)
#2David J. Whellan (Thomas Jefferson University)H-Index: 66
Last. Robert J. Mentz (Duke University)H-Index: 53
view all 8 authors...
Abstract null null Background null Prior studies showed an attenuated response to exercise training among patients with heart failure and type 2 diabetes mellitus. We explored the interaction between diabetes status and a novel, transitional, tailored, progressive rehabilitation intervention that improved physical function compared with usual care in the Rehabilitation Therapy in Older Acute Heart Failure Patients (REHAB-HF) trial. null null null Methods null The effect of the intervention on 3-...
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#1Robert J. Mentz (Duke University)H-Index: 53
#2David J. Whellan (Thomas Jefferson University)H-Index: 66
Last. Paul B. Rosenberg (Duke University)H-Index: 58
view all 13 authors...
Abstract null null Objectives null This study assessed for treatment interactions by ejection fraction (EF) subgroup (≥45% [preserved EF (HFpEF); vs null null null Background null The REHAB-HF trial showed that an early multidomain rehabilitation intervention improved physical function, frailty, quality-of-life, and depression in older patients hospitalized with acute decompensated heart failure (ADHF). null null null Methods null Three-month outcomes were: Short Physical Performance Battery (SP...
3 CitationsSource
#1Haider J. Warraich (Brigham and Women's Hospital)H-Index: 24
#2Dalane W. Kitzman (Wake Forest University)H-Index: 103
Last. David J. Whellan (Thomas Jefferson University)H-Index: 66
view all 7 authors...
Abstract null null Background null We assessed the prevalence and clinical characteristics of patients with acute decompensated heart failure (ADHF) who live alone and how they were different from patients who lived with someone else. null null null Methods null We analyzed patients in the REHAB-HF Trial. Patients were ≥60 years with preserved or reduced ejection fraction who were hospitalized with ADHF. null null null Results null Of 202 patients, 67 (33.2%) lived alone. Patients who lived alon...
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#1David J. Whellan (Thomas Jefferson University)H-Index: 66
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#1Melissa A. Daubert (Duke University)H-Index: 13
#2Eric Yow (Durham University)H-Index: 22
Last. G. Michael Felker (Duke University)H-Index: 94
view all 15 authors...
Background NT-proBNP (N-terminal pro-B-type natriuretic peptide) is a prognostic biomarker in heart failure (HF) with reduced ejection fraction. However, it is unclear whether there is a sex difference in NT-proBNP response and whether the therapeutic goal of NT-proBNP ≤1000 pg/mL has equivalent prognostic value in men and women with HF with reduced ejection fraction. Methods and Results In a secondary analysis of the GUIDE-IT (Guiding Evidence Based Therapy Using Biomarker Intensified Treatment...
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#1Amer I. Aladin (Wake Forest University)H-Index: 6
#2David J. Whellan (Thomas Jefferson University)H-Index: 66
Last. Dalane W. Kitzman (Wake Forest University)H-Index: 103
view all 10 authors...
BACKGROUND Older patients with acute decompensated heart failure (ADHF) have severely impaired physical function (PF) and quality of life (QOL). However, relationships between impairments in PF and QOL are unknown but are relevant to clinical practice and trial design. METHODS We assessed 202 consecutive patients hospitalized with ADHF in the multicenter Rehabilitation Therapy in Older Acute HF Patients (REHAB-HF) Trial. PF measures included Short Physical Performance Battery (SPPB) and 6-min wa...
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#1Jeremy A. Brooksbank (Cleveland Clinic)H-Index: 2
#2Stephen J. Greene (Duke University)H-Index: 38
Last. Robert J. Mentz (Duke University)H-Index: 53
view all 11 authors...
Recognizing that body surface area (BSA) is a commonly used metric to inform medication dosing across fields of medicine, it is possible that patients with heart failure with reduced ejection fraction (HFrEF) with higher BSA may be more likely to tolerate higher doses of GDMT. Using the HF-ACTION trial, we examined 1) the relationship between BSA and achievement of target dosing of evidence-based beta-blocker and angiotensin-converting enzyme inhibitor (ACEI) therapy, and 2) the associations and...
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#1Amy M. Pastva (Duke University)H-Index: 12
#2Christina E. Hugenschmidt (Wake Forest University)H-Index: 20
Last. Pamela W. Duncan (Wake Forest University)H-Index: 95
view all 10 authors...
Abstract Background Older adults with acute decompensated heart failure have persistently poor clinical outcomes. Cognitive impairment (CI) may be a contributing factor. However, the prevalence of CI and the relationship of cognition with other patient-centered factors such a physical function and quality of life (QOL) that also may contribute to poor outcomes are incompletely understood. Methods and Results Older (≥60 years) hospitalized patients with acute decompensated heart failure were asse...
3 CitationsSource
#1K.Y. Feng (Stanford University)H-Index: 1
#2Christopher M. O'Connor (Duke University)H-Index: 145
Last. Robert J. Mentz (Duke University)H-Index: 53
view all 8 authors...
We examined the relationship between pain severity and outcomes in patients with heart failure with reduced ejection fraction (HFrEF) in the HF-ACTION randomized controlled trial. Trends of health-related quality of life (HRQoL) measures grouped by patients' self-reported baseline bodily pain severity were compared using correlation tests, and the association between pain severity and clinical outcomes (including a primary composite endpoint of all-cause mortality and all-cause hospitalization) ...
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#1Tanuka Datta (Thomas Jefferson University)
#2Andrew J. Lee (Thomas Jefferson University)H-Index: 1
Last. David J. Whellan (Thomas Jefferson University)H-Index: 66
view all 5 authors...
Obesity is a growing worldwide epidemic with significant economic burden that carries with it impacts on every physiologic system including the cardiovascular system. Specifically, the risk of heart failure has been shown to increase dramatically in obese individuals. The purpose of this review is to provide background on the individual burdens of heart failure and obesity, followed by exploring proposed physiologic mechanisms that interconnect these conditions, and furthermore introduce treatme...
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