Isabella Barajon
Humanitas University
AnatomyComplement systemCancerInternal medicineEndocrinologyInnate immune systemPathologyReceptorImmunologyPentraxinsInflammationEnteric nervous systemCisplatinCytokineTLR7Spinal cordTriple-Negative Breast CarcinomaCancer researchCentral nervous systemMedicineBiologyImmune systemCell biology
Publications 37
#1Francesca Arnaboldi (University of Milan)H-Index: 11
#2Michele Sommariva (University of Milan)H-Index: 16
Last. Isabella Barajon (Humanitas University)H-Index: 17
view all 10 authors...
BACKGROUND: Toll-Like Receptors (TLRs) play a critical role in the innate and adaptive immune system. They are the mammalian orthologs of Drosophila melanogaster protein Toll, which has been proved to have an early morphogenetic role in invertebrate embryogenesis that in the adult switches to an immune function. AIM: The aim of this study was to evaluate the expression of TLR4 and TLR7 during dorsal root ganglia (DRG), paravertebral ganglia (PVG), and enteric nervous system (ENS) murine developm...
#1Margarita Kirienko (Humanitas University)H-Index: 20
#2Gaia Ninatti (Humanitas University)H-Index: 3
Last. Arturo Chiti (Humanitas University)H-Index: 54
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OBJECTIVES: We aimed to assess the ability of radiomics, applied to not-enhanced computed tomography (CT), to differentiate mediastinal masses as thymic neoplasms vs lymphomas. METHODS: The present study was an observational retrospective trial. Inclusion criteria were pathology-proven thymic neoplasia or lymphoma with mediastinal localization, availability of CT. Exclusion criteria were age < 16 years and mediastinal lymphoma lesion < 4 cm. We selected 108 patients (M:F = 47:61, median age 48 y...
4 CitationsSource
#1Giulia Lamiani (University of Milan)H-Index: 13
#2Paola Dordoni (UNIPV: University of Pavia)H-Index: 6
Last. Isabella Barajon (Humanitas University)H-Index: 17
view all 4 authors...
Background. Several studies have highlighted the benefits of empathy in healthcare settings. A correlation between clinicians’ empathy and patients’ adherence and satisfaction, as well as the ability for the clinician to accurately assess family members' needs, has been found. However, empathy is often seen by clinicians as a risk factor for their wellbeing. This study aims to assess whether the level of empathy of clinicians working in critical care settings may expose them to moral distress, p...
1 CitationsSource
#1Alberto Mantovani (QMUL: Queen Mary University of London)H-Index: 200
#2Isabella Barajon (Humanitas University)H-Index: 17
Last. Cecilia Garlanda (Humanitas University)H-Index: 84
view all 3 authors...
The financial support of Fondazione Cariplo (Contract no. 2015-0564), Ministero della Salute (RF-2011-02348358 and RF-2013-02355470), Ministry of Education, University and Research (PRIN 2015YYKPNN), the European Research Council (ERC – No. 669415 to A. M.), and the Italian Association for Cancer Research (AIRC IG-19014 and AIRC 5x1000-9962) is gratefully acknowledged
113 CitationsSource
#1Irene Corradini (National Research Council)H-Index: 14
#2Elisa Focchi (National Research Council)H-Index: 3
Last. Michela Matteoli (National Research Council)H-Index: 68
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The association between maternal infection and neurodevelopmental defects in progeny is well established, although the biological mechanisms and the pathogenic trajectories involved have not been defined.
39 CitationsSource
#1Kenji DaigoH-Index: 15
#2Antonio Inforzato (University of Milan)H-Index: 24
Last. Alberto Mantovani (Humanitas University)H-Index: 200
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Summary Humoral fluid phase pattern recognition molecules (PRMs) are a key component of the activation and regulation of innate immunity. Humoral PRMs are diverse. We focused on the long pentraxin PTX3 as a paradigmatic example of fluid phase PRMs. PTX3 acts as a functional ancestor of antibodies and plays a non-redundant role in resistance against selected microbes in mouse and man and in the regulation of inflammation. This molecule interacts with complement components, thus modulating complem...
49 CitationsSource
#1Sonia MazzitelliH-Index: 4
#2Fabia Filipello (Humanitas University)H-Index: 9
Last. Michela MatteoliH-Index: 68
view all 11 authors...
Substantial data indicate that amyloid-β (Aβ), the major component of senile plaques, plays a central role in Alzheimer’s Disease and indeed the assembly of naturally occurring amyloid peptides into cytotoxic aggregates is linked to the disease pathogenesis. Although Aβ42 is a highly aggregating form of Aβ, the co-occurrence of shorter Aβ peptides might affect the aggregation potential of the Aβ pool. In this study we aimed to assess whether the structural behavior of human Aβ42 peptide inside t...
15 CitationsSource
#1Martina MolgoraH-Index: 13
#2Isabella Barajon (Humanitas University)H-Index: 17
Last. Cecilia GarlandaH-Index: 84
view all 4 authors...
Interleukin-1 receptor family members (ILRs) and Toll Like Receptors (TLRs) are characterized by the presence of a conserved intracellular domain, the Toll/IL-1resistance (TIR) domain and are key players in immunity and inflammation. ILR and TLR signalling is tightly regulated at different levels. All cell types of the innate immune system express ILRs and TLRs. In addition, IL-1 family members are emerging as key players in the differentiation and function of innate and adaptive lymphoid cells....
34 CitationsSource
#1Sebastien JaillonH-Index: 20
#2Andrea PonzettaH-Index: 14
Last. Alberto MantovaniH-Index: 200
view all 7 authors...
The innate immune system comprises both a cellular and a humoral arm. Neutrophils are key effector cells of the immune and inflammatory responses and have emerged as a major source of humoral pattern recognition molecules (PRMs). These molecules, which include collectins, ficolins, and pentraxins, are specialised in the discrimination of self versus non-self and modified-self and share basic multifunctional properties including recognition and opsonisation of pathogens and apoptotic cells, activ...
7 CitationsSource
#1Francesca Arnaboldi (University of Milan)H-Index: 11
#2Alessandra Menon (University of Milan)H-Index: 8
view all 11 authors...
Sperm protein 17 (Sp17) was originally identified in the flagellum of spermatozoa and subsequently included in the subfamily of tumor-associated antigens known as cancer-testes antigens (CTA). Sp17 has been associated with the motility and migratory capacity in tumor cells, representing a link between gene expression patterns in germinal and tumor cells of different histological origins. Here we review the relevance of Sp17 expression in the mouse embryo and cancerous tissues, and present additi...
5 CitationsSource