Kenneth P. Nephew
Indiana University
CancerInternal medicinemicroRNAGene expressionMolecular biologyEstrogen receptor alphaDNA methylationMetastasisOvarian cancerMethylationEpigeneticsCancer researchBreast cancerGeneticsCancer stem cellCarcinogenesisMedicineEstrogen receptorBiologyCancer cell
Publications 278
#1Margarite D. Matossian (Tulane University)H-Index: 8
#2Van T. Hoang (Tulane University)H-Index: 8
Last. Matthew E. Burow (Tulane University)H-Index: 60
view all 14 authors...
Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited targeted therapeutic options. A defining feature of TNBC is the propensity to metastasize and acquire resistance to cytotoxic agents. Mitogen activated protein kinase (MAPK) and extracellular regulated kinase (ERK) signaling pathways have integral roles in cancer development and progression. While MEK5/ERK5 signaling drives mesenchymal and migratory cell phenotypes in breast cancer, the specific mechanism...
#1Margarite D. Matossian (Tulane University)H-Index: 8
#2Steven G. ElliottH-Index: 13
view all 21 authors...
PURPOSE Breast cancer remains a prominent global disease affecting women worldwide despite the emergence of novel therapeutic regimens. Metastasis is responsible for most cancer-related deaths, and acquisition of a mesenchymal and migratory cancer cell phenotypes contributes to this devastating disease. The utilization of kinase targets in drug discovery have revolutionized the field of cancer research but despite impressive advancements in kinase-targeting drugs, a large portion of the human ki...
#1Van T. Hoang (Tulane University)H-Index: 8
#2Margarite D. Matossian (Tulane University)H-Index: 8
Last. Matthew E. Burow (Tulane University)H-Index: 60
view all 22 authors...
Triple-negative breast cancer (TNBC) presents a clinical challenge due to the aggressive nature of the disease and a lack of targeted therapies. Constitutive activation of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway has been linked to chemoresistance and metastatic progression through distinct mechanisms, including activation of epithelial-to-mesenchymal transition (EMT) when cells adopt a motile and invasive phenotype through loss of epithelia...
#1Hope E. BurksH-Index: 9
view all 12 authors...
#1Alexandra B. Bentz (IU: Indiana University)H-Index: 12
#2Elizabeth M. George (IU: Indiana University)H-Index: 3
Last. Kimberly A. Rosvall (IU: Indiana University)H-Index: 16
view all 8 authors...
Periods of social instability can elicit adaptive phenotypic plasticity to promote success in future competition. However, the underlying molecular mechanisms have primarily been studied in captive and laboratory-reared animals, leaving uncertainty as to how natural competition among free-living animals affects gene activity. Here, we experimentally generated social competition among wild, cavity-nesting female birds (tree swallows, Tachycineta bicolor). After territorial settlement, we reduced ...
#1Weini Wang (IU: Indiana University)H-Index: 2
#2Fang Fang (IU: Indiana University)H-Index: 24
Last. Kenneth P. Nephew (IU: Indiana University)H-Index: 70
view all 4 authors...
Ovarian cancer is a chemoresponsive tumor with very high initial response rates to standard therapy consisting of platinum/paclitaxel. However, most women eventually develop recurrence, which rapidly evolves into chemo-resistant disease. Persistence of ovarian cancer stem cells (OCSC) at the end of therapy has been shown to contribute to resistant tumors. In this study, we demonstrate that the long non-coding RNA HOTAIR is overexpressed in HGSOC cell lines. Furthermore, HOTAIR expression was upr...
#1Monal Patel (NU: Northwestern University)H-Index: 8
#2Yinu Wang (NU: Northwestern University)H-Index: 8
Last. Marcus E. Peter (NU: Northwestern University)H-Index: 92
view all 9 authors...
Numerous micro(mi)RNAs (short noncoding RNAs that negatively regulate gene expression) have been linked to platinum (Pt) sensitivity and resistance in ovarian cancer (OC). miRNA activity occurs when the guide strand of the miRNA, with its seed sequence (pos. 2-7/8), is loaded into the RNA induced silencing complex (RISC) and targets complementary short seed matches in the 39 untranslated region of mRNAs. Toxic seeds, targeting genes critical for cancer cell survival, have been found in tumor sup...
#1Riddhi Sood (IU: Indiana University)H-Index: 1
Last. Heather M. O'HaganH-Index: 16
view all 6 authors...
High grade serous ovarian cancer (HGSOC) is the most common and aggressive type of ovarian cancer. Platinum resistance is a common occurrence in HGSOC and a main cause of tumor relapse resulting in high patient mortality rates. Recurrent ovarian cancer is enriched in aldehyde dehydrogenase (ALDH)+ ovarian cancer stem cells (OCSCs), which are resistant to platinum agents. We demonstrated that acute platinum treatment induced a DNA damage-dependent decrease in BRCA1 levels through BRCA1 promoter D...
#1Lari Wenzel (UCI: University of California, Irvine)H-Index: 32
#2Kathryn Osann (UCI: University of California, Irvine)H-Index: 70
Last. Michael J. Birrer (University of Arkansas for Medical Sciences)H-Index: 4
view all 27 authors...
BACKGROUND There is a critical need to identify patient characteristics associated with long-term ovarian cancer survival. METHODS Quality of life (QOL), measured by the Functional Assessment of Cancer Therapy-Ovarian-Trial Outcome Index (FACT-O-TOI), including physical, functional and ovarian-specific subscales, was compared between long-term (LTS) (8+ years) and short-term (STS) (<5 years) survivors of GOG 218 at baseline, before cycles 4, 7, 13, 21, and 6 months post-treatment using linear an...
#1Yiming FangH-Index: 1
Last. Anirban K. MitraH-Index: 18
view all 7 authors...