Nicolás Ríos-Lombardía
University of Oviedo
One-pot synthesisAmine gas treatingEnantioselective synthesisIonic liquidCatalysisOrganic chemistryEnzymeEutectic systemChemistryBiocatalysisCombinatorial chemistryDesymmetrizationKetoneSubstituentLipaseRing (chemistry)DiamineKinetic resolutionReaction conditionsEnantiomeric excessEnantiomerEnzyme catalysisStereochemistryEnantiopure drug
Publications 48
Abstract A novel series of enantiopure naphthalimide-cycloalkanediamine conjugates were designed, synthetized and evaluated for in vitro cytotoxicity against human colon adenocarcinoma (LoVo), human lung adenocarcinoma (A549), human cervical carcinoma (Hela) and human promyelocytic leukemia cell lines (HL-60). The cytotoxicity of the compounds was highly dependent on size and relative stereochemistry of the cycloalkyl ring as well as length of the spacer. By contrast, any kind of enantioselectio...
#1Aline Telzerow (Graz University of Technology)H-Index: 3
#2Juraj Paris (Bielefeld University)H-Index: 3
Last. Kerstin Steiner (Graz University of Technology)H-Index: 19
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Amine transaminases (ATAs) are used to synthesize enantiomerically pure amines, which are building blocks for pharmaceuticals and agrochemicals. R-selective ATAs belong to the fold type IV PLP-dependent enzymes, and different sequence-, structure- and substrate scope-based features have been identified in the past decade. However, our knowledge is still restricted due to the limited number of characterized (R)-ATAs, with additional bias towards fungal origin. We aimed to expand the toolbox of (R...
#2Luciana Cicco (University of Bari)H-Index: 7
Last. Javier González-SabínH-Index: 22
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The Meyer-Schuster rearrangement of propargylic alcohols into α,β-unsaturated carbonyl compounds has been revisited by setting up an atom-economic process catalyzed by a deep eutectic solvent FeCl3·6H2O/glycerol. Isomerizations take place smoothly, at room temperature, under air and with short reaction times. The unique solubilizing properties of the eutectic mixture enabled the use of a substrate concentration up to 1.0 M with the medium being recycled up to ten runs without any loss of catalyt...
2 CitationsSource
#1David Elorriaga (University of Oviedo)H-Index: 2
#2María J. Rodríguez-Álvarez (University of Oviedo)H-Index: 9
Last. Joaquín García-Álvarez (University of Oviedo)H-Index: 30
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A tandem protocol to access tertiary alcohols has been developed which combines the organocatalytic oxidation of secondary alcohols to ketones followed by their chemoselective addition by several RLi reagents. Reactions take place at room temperature, under air and in aqueous solutions, a trio of conditions that are typically forbidden in polar organometallic chemistry.
4 CitationsSource
#1Luciana CiccoH-Index: 7
#2Antonio SalomoneH-Index: 21
Last. Vito CapriatiH-Index: 32
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: We first report that highly polarized organometallic compounds of s-block elements add smoothly to chiral N - tert -butanesulfinyl imines in the biodegradable D-sorbitol/choline chloride eutectic mixture, thereby granting access to enantioenriched amines after quantitatively deblocking the sulfinyl group. The practicability of the methodology was further highlighted by (a) working at ambient temperature and under air, (b) very short reaction times (2 min), (c) the preparation of diastereomeric...
6 CitationsSource
#1Luciana Cicco (University of Bari)H-Index: 7
#2Antonio SalomoneH-Index: 21
Last. Vito Capriati (University of Bari)H-Index: 32
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#2María J. Rodríguez-Álvarez (University of Oviedo)H-Index: 9
Last. Joaquín García-Álvarez (University of Oviedo)H-Index: 30
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The self-assembly of styrene-type olefins into the corresponding stilbenes was conveniently performed in the Deep Eutectic Solvent (DES) mixture 1ChCl/2Gly under air and in the absence of hazardous organic co-solvents using a one-pot chemo-biocatalytic route. Here, an enzymatic decarboxylation of p-hydroxycinnamic acids sequentially followed by a ruthenium-catalyzed metathesis of olefins has been investigated in DES solvent. Moreover, and to extend the design of chemoenzymatic processes in DESs,...
8 CitationsSource
#1Lisa Marx (KTH: Royal Institute of Technology)H-Index: 3
Last. Per Berglund (KTH: Royal Institute of Technology)H-Index: 29
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A chemoenzymatic approach has been developed for the preparation of sertraline, an established anti-depressant drug. Ketoreductases (KREDs) were employed to yield a key chiral precursor. The biored ...
6 CitationsSource
#1Olha Sviatenko (University of Greifswald)H-Index: 1
Last. Matthias Höhne (University of Greifswald)H-Index: 22
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1 CitationsSource
#1Anna Katharina Schweiger (Graz University of Technology)H-Index: 4
Last. Robert Kourist (Graz University of Technology)H-Index: 23
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Phenolic acid decarboxylase from Bacillus subtilis (BsPAD) converts several p-hydroxycinnamic acid derivatives into the corresponding p-hydroxystyrenes, which are considered to be promising bio-based aromatic chemicals. Despite the enzyme’s high activity and stability, the low solubility of its substrates presents severe limitations for the establishment of industrial processes. Accordingly, deep eutectic solvents (DESs) have emerged as interesting alternatives to aqueous or organic solvents and...
12 CitationsSource