Salvatore Sotgia
University of Sassari
AnalyteDetection limitInternal medicineEndocrinologyChemistryOxidative stressCOPDInflammationDerivatizationHomocysteineArginineCysteineAsymmetric dimethylarginineThiolCapillary electrophoresisElectrophoresisChromatographyGlutathioneBiochemistryMedicineBiology
144Publications
25H-index
1,900Citations
Publications 145
Newest
#1Gian Luca ErreH-Index: 17
#2Matteo PigaH-Index: 27
Last. Mario PescatoriH-Index: 33
view all 11 authors...
To explore the post-transcriptional regulation of the peripheral blood mononuclear cells (PBMCs) transcriptome by microRNAs in Behcet's disease (BD).Using TaqMan Low Density Array-based microRNAs expression profiling, the expression of 750 mature human microRNAs in PBMCs from 5 BD patients and 3 healthy controls (HC) was compared. The expression of deregulated microRNAs was then validated by quantitative real time-polymerase chain reaction (qRT-PCR), in 42 BD patients and 8 HC.In the initial scr...
17 Citations
#1Salvatore Sotgia (University of Sassari)H-Index: 25
#2Angelo Zinellu (University of Sassari)H-Index: 31
Last. Sergio Ledda (University of Sassari)H-Index: 27
view all 10 authors...
Abstract l -ergothioneine levels were measured in amniotic fluid of pregnant sheep after natural mating and transfer of vitrified/thawed in-vitro produced embryos. Amniotic fluids were collected between 60 and 65 and 80–85 days of gestation and analysed by an ultra-performance liquid chromatographic (UPLC) method with fluorescence detection. l -Ergothioneine concentrations ranged between 0.23 and 9.36 μmol/L and were significantly higher in pregnancy obtained by the transfer of vitrified/thawed ...
6 CitationsSource
#1Angelo Zinellu (University of Sassari)H-Index: 31
#2Salvatore Sotgia (University of Sassari)H-Index: 25
Last. Gianfranco Pintus (University of Sassari)H-Index: 32
view all 9 authors...
Epicatechin (EC), epigallocatechin (EGC), epicatechingallate (ECG) and epigallocatechingallate (EGCG) are antioxidants present in the green tea, a widely used beverage whose health benefits are largely recognized. Nevertheless, major physicochemical limitations, such as the high instability of catechins, pose important questions concerning their potential pharmacological use. Recent studies indicate that binding of catechins with plasmatic proteins may modulate their plasma concentration, tissue...
17 CitationsSource
#1Angela Baralla (University of Sassari)H-Index: 7
#2Elisabetta Sotgiu (University of Sassari)H-Index: 9
Last. Luca Deiana (University of Sassari)H-Index: 32
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The role of Clusterin in attenuation of inflammation and reverse cholesterol transfer makes this molecule a potential candidate as a marker for cancer, cardiovascular disease, diabetes mellitus, and metabolic syndrome. In elderly subjects cardiovascular diseases represent the primary cause of death and different clinical studies have shown a positive correlation of these diseases with changes in the lipid pattern. This work aimed at evaluating the relationship between circulating clusterin and t...
22 CitationsSource
#1Mauro Forteschi (University of Sassari)H-Index: 6
#2Salvatore Sotgia (University of Sassari)H-Index: 25
Last. Ciriaco Carru (University of Sassari)H-Index: 38
view all 8 authors...
Phenylalanine, tyrosine, and tryptophan, also known as aromatic amino acids, are involved in many physiological and pathophysiological conditions and are indicative of the liver and kidney function. In this work, we describe a simple and accurate method for their simultaneous quantification, in a single capillary electrophoresis run. This method requires minimal sample manipulation, no derivatization procedures, and methyl tryptophan as internal standard. The human blood plasma sample was precip...
15 CitationsSource
#1Anna Maria Posadino (University of Sassari)H-Index: 19
#2A Cossu (University of Sassari)H-Index: 14
Last. Gianfranco Pintus (University of Sassari)H-Index: 32
view all 10 authors...
Abstract Studies analyzing the impact of natural antioxidants (NA) on Endothelial Cells (ECs) have dramatically increased during the last years, since a deregulated ECs redox state is at the base of the onset and progression of several cardiovascular diseases. However, whether NA can provide cardiovascular benefits is still a controversial area of debate. Resveratrol (RES), a natural polyphenol found in grapes, is believed to provide cardiovascular benefits by virtue of its antioxidant effect on...
40 CitationsSource
#1Salvatore Sotgia (University of Sassari)H-Index: 25
#2Angelo Zinellu (University of Sassari)H-Index: 31
Last. Luisa Bogliolo (University of Sassari)H-Index: 24
view all 9 authors...
The aim of this study was to evaluate the concentration of l-ergothioneine in follicular fluid of some domestic farm animals, such as mare, sheep, goat, sow, and unweaned lamb. The group of unweaned lambs was the cluster with the lowest mean concentration (0.12 ± 0.06 μmol/L), while the mares showed the highest mean values (3.16 ± 1.27 μmol/L). The mean levels in the sheep and goats were similar (0.72 ± 0.21 vs. 0.73 ± 0.50 μmol/L), while the mean values in the sows were slightly higher (1.04 ± ...
2 CitationsSource
#1S. Nieddu (University of Sassari)H-Index: 6
#2Francesca Mossa (University of Sassari)H-Index: 18
Last. Sergio Ledda (University of Sassari)H-Index: 27
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Abstract In vitro embryo production (IVP) and cryopreservation are associated with a high incidence of pregnancy complications and fetal abnormalities that may be linked with alterations of placental development. The amniotic fluid is partly derived from the transport of water and solutes across the placenta and provides the fetus with amino acids (AAs), which are the building blocks for biomolecules involved in physiological growth and development. To better understand the anomalies associated ...
5 CitationsSource
#1Angelo Zinellu (University of Sassari)H-Index: 31
#2Salvatore Sotgia (University of Sassari)H-Index: 25
Last. Ciriaco Carru (University of Sassari)H-Index: 38
view all 6 authors...
Abstract Background and aim Tryptophan (Trp) degradation via indoleamine (2,3)-dioxygenase (IDO), with consequent increased in kynurenine (Kyn) concentrations, has been proposed as marker of immune system activation. Oxidative stress (OS) might contribute to the pro-inflammatory state in chronic kidney disease (CKD) through the activation of NF-kB, with consequent activation and recruitment of immune cells. Methods and results Serum concentrations of Trp and Kyn, oxidative stress indices malondi...
20 CitationsSource
#1Francesco Blasetti (University of Sassari)H-Index: 6
#2Donatella Usai (University of Sassari)H-Index: 19
Last. Antonio Daniele Pinna (University of Sassari)H-Index: 80
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Introduction: The study aimed to investigate whether the preparation, storage, and use of autologous serum in insulin syringes is microbiologically safe. Methodology: Blood samples (10 mL) were obtained from 10 volunteers. After centrifugation, the supernatant serum was removed and distributed in 5 sterile insulin syringes for each sample; syringes were numbered 0 to 4 and labelled with the subject’s details. Syringes were immediately transported to the microbiology laboratory and stored in a re...
6 CitationsSource