Janet S. Soul
Boston Children's Hospital
Internal medicineEtiologySurgeryMagnetic resonance imagingCerebral blood flowCardiologyIntensive care medicineHemodynamicsPediatricsProspective cohort studyHypothermiaNeonatal encephalopathyEpilepsyGestational ageEncephalopathyCentral nervous system diseaseNeonatal seizureHypoxic Ischemic EncephalopathySymptomatic seizuresAnesthesiaBirth weightMedicine
Publications 102
#1Renée A. Shellhaas (UM: University of Michigan)H-Index: 32
#2Courtney J. Wusthoff (Stanford University)H-Index: 28
Last. Cameron Thomas (UC: University of Cincinnati)H-Index: 8
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OBJECTIVE We aimed to evaluate early-life epilepsy incidence, seizure types, severity, risk factors, and treatments among survivors of acute neonatal seizures. METHODS Neonates with acute symptomatic seizures born 7/2015-3/2018 were prospectively enrolled at nine Neonatal Seizure Registry sites. One-hour EEG was recorded at age three months. Post-neonatal epilepsy and functional development (Warner Initial Developmental Evaluation of Adaptive and Functional Skills - WIDEA-FS) were assessed. Cox ...
#1Courtney J. Wusthoff (Stanford University)H-Index: 28
#2Vandana Sundaram (Stanford University)H-Index: 25
Last. Renée A. Shellhaas (UM: University of Michigan)H-Index: 32
view all 15 authors...
OBJECTIVE To determine whether screening continuous EEG monitoring (cEEG) is associated with greater odds of treatment success for neonatal seizures. METHODS We included term neonates with acute symptomatic seizures enrolled in the Neonatal Seizure Registry (NSR), a prospective, multicenter cohort of neonates with seizures. We compared two cEEG approaches: (1) Screening cEEG, initiated for indications of encephalopathy or paralysis without suspected clinical seizures, and (2) Confirmatory cEEG, ...
#1Hannah C. Glass (UCSF: University of California, San Francisco)H-Index: 37
#2Janet S. Soul (Boston Children's Hospital)H-Index: 37
Last. Renée A. Shellhaas (UM: University of Michigan)H-Index: 32
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Importance Antiseizure medication (ASM) treatment duration for acute symptomatic neonatal seizures is variable. A randomized clinical trial of phenobarbital compared with placebo after resolution of acute symptomatic seizures closed early owing to low enrollment. Objective To assess whether ASM discontinuation after resolution of acute symptomatic neonatal seizures and before hospital discharge is associated with functional neurodevelopment or risk of epilepsy at age 24 months. Design, Setting, ...
1 CitationsSource
#1Emily M. Herzberg (Harvard University)H-Index: 2
#2Jessica Landers (Boston Children's Hospital)
Last. Janet S. Soul (Boston Children's Hospital)H-Index: 37
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BACKGROUND: Encephalopathy severity in neonates evaluated for therapeutic hypothermia (TH) has traditionally been determined by neurologic exam, sometimes alongside amplitude-integrated electroencephalogram (aEEG). The original 1976 report describing the progressive stages of encephalopathy (PMID 987769) led to modified versions of the Sarnat exam, which were utilized in randomized trials evaluating TH, with or without aEEG. However, there has been minimal validation of exam scores as measures o...
#1Janet S. Soul (Boston Children's Hospital)H-Index: 37
#2Ann M. Bergin (Boston Children's Hospital)H-Index: 20
Last. Kevin J. Staley (Harvard University)H-Index: 58
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OBJECTIVE In the absence of controlled trials, treatment of neonatal seizures has changed minimally despite poor drug efficacy. We tested bumetanide added to phenobarbital to treat neonatal seizures in the first trial to include a standard-therapy control group. METHODS A randomized, double-blind, dose-escalation design was employed. Neonates with postmenstrual age 33 to 44 weeks at risk of or with seizures were eligible. Subjects with electroencephalography (EEG)-confirmed seizures after ≥20 an...
4 CitationsSource
#1Caitlin K. Rollins (Harvard University)H-Index: 14
#2Cynthia M. Ortinau (WashU: Washington University in St. Louis)H-Index: 12
Last. Jane W. Newburger (Harvard University)H-Index: 123
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OBJECTIVE Congenital heart disease (CHD) is associated with abnormal brain development in utero. We applied innovative fetal magnetic resonance imaging (MRI) techniques to determine whether reduced fetal cerebral substrate delivery impacts the brain globally, or in a region-specific pattern. Our novel design included two control groups, one with and the other without a family history of CHD, to explore the contribution of shared genes and/or fetal environment to brain development. METHODS From 2...
1 CitationsSource
#1Joshua L. Bonkowsky (UofU: University of Utah)H-Index: 28
#2Gabrielle deVeber (U of T: University of Toronto)H-Index: 85
Last. Janet S. SoulH-Index: 37
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Abstract Background 2020 marked a fundamental shift in the pediatric neurology field. An impressive positive trajectory of advances in patient care and research faced sudden global disruptions by the COVID-19 pandemic and by an international movement protesting racial, socioeconomic, and health disparities. The disruptions revealed obstacles and fragility within the pediatric neurology research mission. However, renewed commitment offers unique opportunites for the pediatric neurology research c...
3 CitationsSource
#1Jungwhan John Choi (Boston Children's Hospital)H-Index: 2
#2Edward Yang (Boston Children's Hospital)H-Index: 28
Last. Camilo Jaimes (Boston Children's Hospital)H-Index: 14
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Fetal MRI is the modality of choice to study supratentorial brain malformations. To accurately interpret the MRI, the radiologist needs to understand the normal sequence of events that occurs during prenatal brain development; this includes familiarity with the processes of hemispheric cleavage, formation of interhemispheric commissures, neuro-glial proliferation and migration, and cortical folding. Disruption of these processes results in malformations observed on fetal MRI including holoprosen...
#1Janet S. SoulH-Index: 37
#2Sarah J. Spence (Boston Children's Hospital)H-Index: 30
* Abbreviations: ASD — : autism spectrum disorder CLD — : chronic lung disease Children born preterm are known to be at higher risk for developing autism spectrum disorder (ASD) compared with their term-born counterparts, with an estimated 7% prevalence of ASD based on a recent large prospective study and a meta-analysis.1,2 This high prevalence is in contrast to the currently estimated prevalence of ASD in the United States of 1.8% in the general population.3 ASD has been shown to be associated...
#1Monica E. Lemmon (Duke University)H-Index: 14
#2Sonia L. Bonifacio (Stanford University)H-Index: 24
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Abstract Background Neonatal seizures are associated with death and neurologic morbidity; however, little is known about how neonates with seizures die. Methods This was a prospective, observational cohort study of neonates with seizures treated at seven sites of the Neonatal Seizure Registry. We characterized mode of death, evaluated the association between infant characteristics and mode of death, and evaluated predictors of death or transfer to hospice. Results We enrolled 611 consecutive neo...