Pathology

Neuroscience

MPTP

Disease

Ischemia

Biology

Cardiology

Mitochondrial permeability transition pore

Apoptosis

Chemistry

Parkinson's disease

Programmed cell death

Mitochondrion

Cell biology

Necrosis

Biochemistry

Medicine

Pharmacology

Journal of Molecular and Cellular Cardiology

Mitochondrial permeability transition pore (mPTP)-dependent cell death is a form of necrotic cell death that is driven by mitochondrial dysfunction by the opening of the mPTP and is triggered by increases in matrix levels of Ca2+ and reactive oxygen species. This form of cell death has been implicated in ischemic injuries of the heart and brain as well as numerous degenerative diseases in the brain and skeletal muscle. This review focuses on the molecular triggers and regulators of mPTP-dependent necrosis in the context of myocardial ischemia reperfusion injury.

Mitochondrial permeability transition pore-dependent necrosis