Hildebrand solubility parameter

Mass fraction

Supercritical carbon dioxide

Engineering

Compatibility (geochemistry)

Chromatography

Fludrocortisone

Solubility

Molality

UNIQUAC

Mole fraction

Non-random two-liquid model

Biochemistry

Solvent

Chemical engineering

Supercritical fluid

Physical chemistry

Thermodynamics

Physics

Organic chemistry

Activity coefficient

Aqueous solution

Analytical Chemistry (journal)

Chemistry

Hydrocortisone

Carbon dioxide

The Journal of Supercritical Fluids

Solubility of pharmaceutical compounds in the supercritical carbon dioxide (sc-CO2) is an essential parameter in the development of the pharmaceutical industry. In this work, the solubility of fludrocortisone acetate was measured in sc-CO2 at the pressure and temperature ranges of 120 − 300 bar and 308–338 K, respectively. Moreover, the experimental solubility data were correlated using several empirical models (Chrastil, Mendez-Santiago & Teja, Bartle, and Kumar & Johnston), a non-cubic equation of state (PC-SAFT), and a UNIQUAC model. The mole fraction of the drug in sc-CO2 was varied in the range of 0.211 × 10-6 to 0.653 × 10-5. The solubility shows a complete dependence on operating pressure and temperature. Furthermore, MST and PC-SAFT models exhibited the highest accuracy with respective Radj values of 0.994 and 0.993. Regarding the poor solubility of FLU in sc-CO2, a supercritical anti-solvent method can be an appropriate choice to produce fine particles of this drug.

Solubility measurement of the fludrocortisone acetate in supercritical carbon dioxide: Experimental and modeling assessments