Framingham Heart Study

Internal medicine

Pulse pressure

Hazard ratio

Disease

Diabetes mellitus

Blood pressure

Gene

Endocrinology

Genotype

Framingham Risk Score

Odds ratio

Cardiology

Arterial stiffness

Chemistry

Type 2 diabetes

Mendelian randomization

Brachial artery

Body mass index

Pulse wave velocity

Genetic variants

Confidence interval

Biochemistry

Medicine

Circulation Research

Microvascular damage from large artery stiffness (LAS) in pancreatic, hepatic, and skeletal muscles may affect glucose homeostasis. Our goal was to evaluate the association between LAS and the risk of type 2 diabetes using prospectively collected, carefully phenotyped measurements of LAS as well as Mendelian randomization analyses.

Arterial Stiffness and Diabetes Risk in Framingham Heart Study and UK Biobank