Physics

Internal medicine

Action (physics)

Biology

Epistemology

Philosophy

Chemistry

Multiple myeloma

Thalidomide

Computer science

Quantum mechanics

Computational biology

Mechanism (biology)

Medicine

Chemical Society Reviews

Thalidomide and its derivatives are the only protein degraders currently used in clinical practice. This tutorial review provides an overview of the mechanism of action of thalidomide-based degraders and their future perspectives.

Discovery of CRBN as a target of thalidomide: a breakthrough for progress in the development of protein degraders