Oligodendrocyte

Demyelinating Disorder

Psychiatry

Immunology

Optic neuritis

Spinal cord

Central nervous system

Internal medicine

Myelin

Experimental autoimmune encephalomyelitis

Multiple sclerosis

Medicine

Myelitis

Myelin oligodendrocyte glycoprotein

Encephalomyelitis

Pathology

Annals of Clinical and Translational Neurology

SARS‐COV‐2 frequently cause neurological disorders and is sometimes associated with onset of autoimmune diseases affecting the nervous system. Over recent years, a rare but distinct diagnosis designated myelin oligodendrocyte glycoprotein‐associated disorder (MOGAD) has been recognized in patients with attacks of optic neuritis, myelitis, or encephalomyelitis and increased levels of anti‐MOG antibodies. The cause of MOGAD is unknown. However, there have been reports of single cases of MOGAD in patients with Covid‐19 infection. We report a series of SARS‐CoV‐2 positive patients that developed MOGAD, but a homology search did not support a cross‐reactive immune response to SARS‐CoV‐2 spike‐protein and MOG.

<scp>SARS‐COV</scp>‐2 a trigger of myelin oligodendrocyte glycoprotein‐associated disorder

SARS‐COV‐2 a trigger of myelin oligodendrocyte glycoprotein‐associated disorder