Internal medicine

Cytokine

Disease

Aerobic exercise

Cancer

Oncology

Immunology

Immunity

Pancreatic cancer

Interleukin

Cancer research

Medicine

Immune system

Cancer Cell

Kurz. et al. discover that aerobic exercise slows pancreatic cancer growth in mice through activation of the immune system, particularly CD8+ T cells. The beneficial effects of exercise can be mimicked by treatment with an IL-15 super-agonist, NIZ985. Exercise or NIZ985 both improve the responsiveness of murine pancreatic tumors to immune- and non-immune- based therapeutics.

Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer