Internal medicine

Retrospective cohort study

Pediatrics

Biology

Gene

Virology

Monkeypox

Vaccinia

Recombinant DNA

Biochemistry

Medicine

The Lancet Infectious Diseases

Cases of human monkeypox are rarely seen outside of west and central Africa. There are few data regarding viral kinetics or the duration of viral shedding and no licensed treatments. Two oral drugs, brincidofovir and tecovirimat, have been approved for treatment of smallpox and have demonstrated efficacy against monkeypox in animals. Our aim was to describe the longitudinal clinical course of monkeypox in a high-income setting, coupled with viral dynamics, and any adverse events related to novel antiviral therapies.

Clinical features and management of human monkeypox: a retrospective observational study in the UK