Gene

Context (archaeology)

Bacteria

Biology

Plant use of endophytic fungi in defense

Glomeromycota

Arbuscular mycorrhizal

Arbuscular mycorrhizal fungi

Biochemistry

Botany

Medicinal plants

Paleontology

Genetics

Biomass (ecology)

Agronomy

Greenhouse

Horticulture

Inoculation

Microorganism

Hydroponics

Secondary metabolite

Symbiosis

Mycorrhiza

Medicinal plants are an important source of therapeutic compounds used in the treatment of many diseases since ancient times. Interestingly, they form associations with numerous microorganisms developing as endophytes or symbionts in different parts of the plants. Within the soil, arbuscular mycorrhizal fungi (AMF) are the most prevalent symbiotic microorganisms forming associations with more than 70% of vascular plants. In the last decade, a number of studies have reported the positive effects of AMF on improving the production and accumulation of important active compounds in medicinal plants.In this work, we reviewed the literature on the effects of AMF on the production of secondary metabolites in medicinal plants. The major findings are as follows: AMF impact the production of secondary metabolites either directly by increasing plant biomass or indirectly by stimulating secondary metabolite biosynthetic pathways. The magnitude of the impact differs depending on the plant genotype, the AMF strain, and the environmental context (e.g., light, time of harvesting). Different methods of cultivation are used for the production of secondary metabolites by medicinal plants (e.g., greenhouse, aeroponics, hydroponics, in vitro and hairy root cultures) which also are compatible with AMF. In conclusion, the inoculation of medicinal plants with AMF is a real avenue for increasing the quantity and quality of secondary metabolites of pharmacological, medical, and cosmetic interest.

Arbuscular mycorrhizal fungi and production of secondary metabolites in medicinal plants