Nanogel

Organic chemistry

Enzyme

Reactive oxygen species

Biology

Activator (genetics)

Gene

Crystal structure

Cancer

Biophysics

Bioorganic chemistry

Chemistry

Singlet oxygen

Drug delivery

Supramolecular chemistry

Cancer therapy

Oxygen

Genetics

Biochemistry

Angewandte Chemie

Neutrophils can responsively release reactive oxygen species (ROS) to actively combat infections by exogenous stimulus and cascade enzyme catalyzed bio‐oxidation. A supramolecular nanogel is now used as an artificial neutrophil by enzymatic interfacial self‐assembly of peptides (Fmoc‐Tyr(H 2 PO 3 )‐OH) with magnetic nanoparticles (MNPs) and electrostatic loading of chloroperoxidase (CPO). The MNPs within the nanogel can elevate H 2 O 2 levels in cancer cells under programmed alternating magnetic field (AMF) similar to the neutrophil activator, and the loaded CPO within protective peptides nanolayer converts the H 2 O 2 into singlet oxygen ( 1 O 2 ) in a sustained manner for neutrophil‐inspired tumor therapy. As a proof of concept study, both the H 2 O 2 and 1 O 2 in cancer cells increase stepwise under a programmed alternating magnetic field. An active enzyme dynamic therapy by magnetically stimulated oxygen stress and sustained enzyme bio‐oxidation is thus shown with studies on both cells and animals.

A Neutrophil‐Inspired Supramolecular Nanogel for Magnetocaloric–Enzymatic Tandem Therapy