Transcription factor

Biology

Gene

Biophysics

Philosophy

Transcription (linguistics)

Linguistics

Cell biology

Genetics

Coactivator

Chromatin

Molecular Cell

Phase separation of TFs into condensates has been proposed to enhance transcription activation. Trojanowski et al. show that a high propensity of TFs to engage in multivalent interactions is needed for their full activation capacity independent of TF assembly into phase-separated liquid-like droplets.

Transcription activation is enhanced by multivalent interactions independent of phase separation