Genome

Adjuvant chemotherapy

Chemotherapy

Adjuvant

Cancer research

Biology

Gene

Cancer

Osteosarcoma

Breast cancer

Internal medicine

Oncology

Genetics

Medicine

New England Journal of Medicine

Osteosarcoma, which is most common in people 10 to 30 years of age, is generally treated with resection and adjuvant chemotherapy. Detection of gene rearrangements, copy-number variations, and targeted disruption of tumor suppressors by whole-genome sequencing has not yet led to improved treatment.

New Horizons in the Treatment of Osteosarcoma