Metal

Catalysis

Adsorption

Metallurgy

Materials science

Reaction mechanism

Metal ions in aqueous solution

Inorganic chemistry

Porosity

Redox

Nanotechnology

Organic chemistry

Biocatalysis

Metal-organic framework

Chemistry

Copper

Advances in Colloid and Interface Science

Metal-organic frameworks (MOFs) are a class of important porous, crystalline materials composed of metal ions (clusters) and organic ligands. Owing to the unique redox chemistry, photochemical and electrical property, and catalytic activity of Cu2+/+, copper-based MOFs (Cu-MOFs) have been recently and extensively explored in various biomedical fields. In this review, we first make a brief introduction to the synthesis of Cu-MOFs and their composites, and highlight the recent synthetic strategies of two most studied representatives, three-dimensional HKUST-1 and two-dimensional Cu-TCPP. The recent advances of Cu-MOFs in the applications of cancer treatment, bacterial inhibition, biosensing, biocatalysis, and wound healing are summarized and discussed. Furthermore, we propose a prospect of the future development of Cu-MOFs in biomedical fields and beyond.

Copper-based metal–organic frameworks for biomedical applications