Eukaryotic Ribosome

Ribosomal RNA

Biology

Gene

Ubiquitin ligase

Ubiquitin

Ribosomal protein

Computational biology

Cell biology

Genetics

Ribosome

Molecular Cell

Filbeck and colleagues discuss recent developments in the understanding of ribosome-associated protein quality control, a pathway conserved from bacteria to humans. They analyze the pathway’s underlying mechanisms, its activation by the stalling of ribosomes during translation and ensuing ribosome collisions, and defects in the components involved leading to neurodegeneration.

Ribosome-associated quality-control mechanisms from bacteria to humans