Drug resistance

Downregulation and upregulation

Fungemia

Candida albicans

Biology

Microbiology

Gene

Multiple drug resistance

Virology

Pathogen

Immunology

Antifungal

Candida auris

Fungal pathogen

Biochemistry

Immune system

mSphere

Candida auris is a globally spreading yeast pathogen causing bloodstream infections with high mortality in critically ill patients. The inherent antifungal drug resistance of most C. auris isolates and threat of multidrug-resistant strains create a need for adjunct immunotherapeutic strategies. While C. albicans candidemia was shown to induce immune paralysis and activation of inhibitory immune checkpoints,

Candida auris Bloodstream Infection Induces Upregulation of the PD-1/PD-L1 Immune Checkpoint Pathway in an Immunocompetent Mouse Model