Original paper
Rapid manufacturing of non-activated potent CAR T cells
Abstract
Chimaeric antigen receptor (CAR) T cells can generate durable clinical responses in B-cell haematologic malignancies. The manufacturing of these T cells typically involves their activation, followed by viral transduction and expansion ex vivo for at least 6 days. However, the activation and expansion of CAR T cells leads to their progressive differentiation and the associated loss of anti-leukaemic activity. Here we show that functional CAR T...
Paper Details
Title
Rapid manufacturing of non-activated potent CAR T cells
Published Date
Feb 21, 2022
Volume
6
Issue
2
Pages
118 - 128