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Original paper

Rapid manufacturing of non-activated potent CAR T cells

Volume: 6, Issue: 2, Pages: 118 - 128
Published: Feb 21, 2022
Abstract
Chimaeric antigen receptor (CAR) T cells can generate durable clinical responses in B-cell haematologic malignancies. The manufacturing of these T cells typically involves their activation, followed by viral transduction and expansion ex vivo for at least 6 days. However, the activation and expansion of CAR T cells leads to their progressive differentiation and the associated loss of anti-leukaemic activity. Here we show that functional CAR T...
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Paper Details
Title
Rapid manufacturing of non-activated potent CAR T cells
Published Date
Feb 21, 2022
Volume
6
Issue
2
Pages
118 - 128
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