Internal medicine

Premature ovarian failure

Infertility

Therapeutic approach

Disease

Hormone replacement therapy (female-to-male)

Bioinformatics

Biology

Intensive care medicine

Reproductive medicine

Testosterone (patch)

Gynecology

Pregnancy

Premature ovarian insufficiency

Genetics

Medicine

Reproductive Biology and Endocrinology

Primary ovarian insufficiency (POI) is a rare gynecological condition. This disease causes menstrual disturbances, infertility, and various health problems. Historically, hormone replacement therapy is the first-line treatment for this disorder. Women diagnosed with POI are left with limited therapeutic options. In order to remedy this situation, a new generation of therapeutic approaches, such as in vitro activation, mitochondrial activation technique, stem cell and exosomes therapy, biomaterials strategies, and platelet-rich plasma intra-ovarian infusion, is being developed. However, these emerging therapies are yet in the experimental stage and require precise design components to accelerate their conversion into clinical treatments. Thus, each medical practitioner bears responsibility for selecting suitable therapies for individual patients. In this article, we provide a timely analysis of the therapeutic strategies that are available for POI patients and discuss the prospects of POI therapy.

Therapeutic options for premature ovarian insufficiency: an updated review