Gene

Hearing loss

Biology

Audiometry

Cohort

Surgery

Etiology

Cohort study

Penetrance

Genetics

Pediatrics

Physics

Retrospective cohort study

Age of onset

Optics

Stapedectomy

Internal medicine

Epidemiology

Family history

Medicine

Otosclerosis

Audiology

Disease

Incidence (geometry)

Phenotype

Otology & Neurotology

To analyse the epidemiology of otosclerosis in a British cohort collected between 2011 and 2017.Retrospective cohort study.Five UK ENT Departments.Patients with surgically confirmed otosclerosis.Questionnaire data documented family history of otosclerosis, age of onset, medical history, and information on associated risk factors for 657 patients. Pre and post-surgical pure-tone audiometry was collected for 154 of these patients.The age of onset, incidence of bilateral disease, tinnitus and vertigo, a higher prevalence of women (65%) than men (35%) are similar to those reported previously for otosclerosis cohorts. No association with measles infection was detected. Patients with a family history (40%) have an earlier age of onset and a higher incidence of bilateral disease and vertigo than non-familial subjects. Pedigree analysis is consistent with an autosomal dominant inheritance with reduced penetrance being apparent in 44/91 pedigrees studied. Women who associate their hearing loss with pregnancy have an earlier age of onset than those that do not (p = 6 × 10).This study confirms that otosclerosis is an early adult onset disease that is more prevalent in women than men with a large minority of patients having a family history of otosclerosis. We report new evidence to support a relationship between pregnancy and otosclerosis progression in a proportion of women. In addition, this is the first study to identify differences in severity between familial and non-familial cases of otosclerosis, highlighting the possibility that more than one etiology may be involved.

The Epidemiology of Otosclerosis in a British Cohort