Function (biology)

Cell biology

Biology

Apoptosis

Autophagy

Protein kinase B

Signal transduction

Biochemistry

AKT1

Mitochondrion

AKT3

PI3K/AKT/mTOR pathway

Aging and Disease

Mitochondrial dysfunction may play a crucial role in various diseases due to its roles in the regulation of energy production and cellular metabolism. Serine/threonine kinase (AKT) is a highly recognized antioxidant, immunomodulatory, anti-proliferation, and endocrine modulatory molecule. Interestingly, increasing studies have revealed that AKT can modulate mitochondria-mediated apoptosis, redox states, dynamic balance, autophagy, and metabolism. AKT thus plays multifaceted roles in mitochondrial function and is involved in the modulation of mitochondria-related diseases. This paper reviews the protective effects of AKT and its potential mechanisms of action in relation to mitochondrial function in various diseases.

Mammalian AKT, the Emerging Roles on Mitochondrial Function in Diseases