GLUE

Adhesive

Adhesion

Engineering

Elastomer

Biomedical engineering

Materials science

Leak

Tissue Adhesion

Surgery

Layer (electronics)

Ultimate tensile strength

Visual arts

Cerebrospinal fluid leak

Environmental engineering

Wet strength

Fibrin glue

Composite material

Sealant

Medicine

Seal (emblem)

Polydimethylsiloxane

Matter

Existing tissue adhesives and sealants are far from satisfactory when applied on wet and dynamic tissues. Herein, we report a strategy for designing biodegradable super-strong aqueous glue (B-Seal) for surgical uses inspired by an English ivy adhesion strategy and a cement particle packing theory. B-Seal is a fast-gelling, super-strong, and elastic adhesive sealant composed of injectable water-borne biodegradable polyurethane (WPU) nanodispersions with mismatched particle sizes and counterions in its A-B formulation. B-Seal showed 24-fold greater burst pressure than DuraSeal®, 138-fold greater T-pull adhesive strength than fibrin glue, and 16-fold greater lap shear strength than fibrin glue. In vivo evaluation on a rat cerebrospinal fluid (CSF) rhinorrhea model and a porcine craniotomy model validated the safety and efficacy of B-Seal for effective CSF leak prevention and dura repair. The plant-inspired adhesion strategy combined with particle packing theory represents a new direction of designing the next-generation wet tissue adhesives for surgeries.

Bioinspired super-strong aqueous synthetic tissue adhesives