Epoxy

Biochemistry

Endocrine system

Environmental health

Reproductive toxicity

Bisphenol A

Organic chemistry

Genotoxicity

Toxicity

Environmental chemistry

Neurotoxicity

Hormone

Medicine

Chemistry

Human health

Endocrine disruptor

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology

Bisphenol A (BPA) is a synthetic organic compound that is mainly used in the production of polymer materials polycarbonate and epoxy resin. Widespread use and irregular processing methods have led to BPA being detected globally, raising concerns about its environmental and health effects. This review outlines an overview of the presence and removal of BPA in the environment and consumer products. We also summarized the endocrine-disrupting toxicity of BPA, and the relatively less summarized neurotoxicity, cytotoxicity, reproductive toxicity, genotoxicity, and carcinogenicity. Human exposure data show that humans have been exposed to low concentrations of BPA for a long time, future research should focus on the long-term exposure and the migration of BPA from consumer products to humans and the possible health risks associated with human exposure to BPA. Exploring economical and effective methods to reduce and remove BPA from the environment is imperative. The development of safe, functional and reproducible BPA analogs and the study of its degradation products can be the focus of subsequent research.

A critical review of presence, removal and potential impacts of endocrine disruptors bisphenol A