Mononegavirales

Viral disease

Virology

Immunity

Immunology

Immune system

Internal medicine

Paramyxoviridae

Immunopathology

Respiratory system

Medicine

Virus

Respiratory tract

Disease

Pathology

Viruses

RSV is a leading cause of respiratory tract disease in infants and the elderly. RSV has limited therapeutic interventions and no FDA-approved vaccine. Gaps in our understanding of virus-host interactions and immunity contribute to the lack of biological countermeasures. This review updates the current understanding of RSV immunity and immunopathology with a focus on interferon responses, animal modeling, and correlates of protection.

Immunopathology of RSV: An Updated Review