Epidemiology

Internal medicine

Pathology

Disease

Quality of life (healthcare)

Bioinformatics

Biology

Cancer

Nursing

Intensive care medicine

Endometrial cancer

Malignancy

Medicine

Nature Reviews Disease Primers

Although endometrial cancer management remains challenging, a deeper understanding of the genetic diversity as well as the drivers of the various pathogenic states of this disease has led to development of divergent management approaches in an effort to improve therapeutic precision in this complex malignancy. This comprehensive review provides an update on the epidemiology, pathophysiology, diagnosis and molecular classification, recent advancements in disease management, as well as important patient quality-of-life considerations and emerging developments in the rapidly evolving therapeutic landscape of endometrial cancers. This Primer by Makker and colleagues summarizes the epidemiology, pathophysiology, diagnosis and treatment of endometrial cancer. Moreover, this Primer discusses the quality-of-life issues faced by women with endometrial cancer and summarizes future research directions.