MHC class II

Dendritic cell

Major histocompatibility complex

Biology

T cell

Interferon

Immunity

MHC class I

Cancer research

Immunology

Genetics

Cross-presentation

Immune system

Antigen

In vitro

Cytotoxic T cell

Tumor-infiltrating dendritic cells (DCs) assume varied functional states that impact anti-tumor immunity. To delineate the DC states associated with productive anti-tumor T cell immunity, we compared spontaneously regressing and progressing tumors. Tumor-reactive CD8

Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity