Salmonella fimbrial protein StcD induces cyclooxygenase-2 expression via Toll-like receptor 4

The genome of Salmonella enterica serovar Typhimurium contains 13 operons with homology to fimbrial genes.To investigate the involvement of these fimbrial gene clusters in the expression of cyclooxygenase-2 (COX-2), which is an inducible enzyme involved in the synthesis of prostanoids, in J774 macrophages infected with S. enterica serovar Typhimurium, we constructed strains carrying a mutation in genes encoding the putative subunit proteins in...