pH low insertion peptide (pHLIP)-decorated polymeric nanovehicle for efficient and pH-responsive siRNA translocation

As a hallmark of most solid tumors, tumor acidic microenvironment aids tumor survival and progression. Tumor acidity also represents a tumor-specific stimulus that has been harnessed for the design and development of pH-responsive drug delivery systems. Pyruvate kinase M2 (PKM2) functions as an oncoprotein in tumorigenesis, and its overexpression in many tumors promotes metabolic rewiring towards aerobic glycolysis. Herein, a pH low insertion...