Biology

Inflammatory bowel disease

Immunology

Colitis

Antibiotics

Microbiology

Inflammation

Internal medicine

Pharmacology

Resveratrol

Gut flora

Medicine

Inflammatory Bowel Diseases

Disease

Food Science and Human Wellness

Inflammatory bowel disease (IBD) is a chronic inflammatory lesion of the intestine, mainly manifested by infiltration of intestinal inflammatory cells and imbalance of gut microbiota. Conventional treatments for IBD include antibiotics, immunosuppressive agents, 5-aminosalicylic acid, steroids and surgery, which have high toxic side effects. Resveratrol is a natural polyphenol, and its various derivatives have anti-oxidation and anti-inflammatory properties. In this paper, we comprehensively review the mechanism of resveratrol and its derivates to alleviate IBD by improving intestinal barrier, regulating the unbalanced gut microbiota, and targeting various inflammatory signaling pathways.

Resveratrol and its derivates improve inflammatory bowel disease by targeting gut microbiota and inflammatory signaling pathways