Messenger RNA

Translation (biology)

Ribosome profiling

Circular RNA

Biology

Gene

Computational biology

Internal ribosome entry site

Cell biology

5.8S ribosomal RNA

Eukaryotic translation

Genetics

Ribosome

Molecular Cell

Chen et al. identified thousands of RNA elements that initiate circRNA translation and discovered key sequence and structural features for their activity. They identify hundreds of circRNA-encoded proteins and characterize circFGFR1 as a dominant-negative FGF receptor that suppresses proliferation during cell stress.

Structured elements drive extensive circular RNA translation