Vasculitis

Social psychology

Inflammatory bowel disease

NOD2

Immunology

Signature (topology)

Immune system

Psychology

Mathematics

Pathophysiology

Cytokine

Geometry

Multiple sclerosis

Medicine

Cognitive reframing

Innate immune system

Tumor necrosis factor alpha

Disease

Giant cell arteritis

Pathology

New England Journal of Medicine

The ability to block specific cytokine pathways has revealed pathophysiological differences among autoimmune diseases (e.g., the efficacy of TNF inhibitors in arthritides and inflammatory bowel disorders and their inefficacy in giant-cell arteritis and multiple sclerosis), providing a framework for reclassification.

Reframing Immune-Mediated Inflammatory Diseases through Signature Cytokine Hubs