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Original paper

Development and validation of a machine-learning ALS survival model lacking vital capacity (VC-Free) for use in clinical trials during the COVID-19 pandemic

Volume: 22, Issue: sup1, Pages: 22 - 32
Published: Jul 30, 2021
Abstract
Vital capacity (VC) is routinely used for ALS clinical trial eligibility determinations, often to exclude patients unlikely to survive trial duration. However, spirometry has been limited by the COVID-19 pandemic. We developed a machine-learning survival model without the use of baseline VC and asked whether it could stratify clinical trial participants and a wider ALS clinic...
Paper Details
Title
Development and validation of a machine-learning ALS survival model lacking vital capacity (VC-Free) for use in clinical trials during the COVID-19 pandemic
Published Date
Jul 30, 2021
Volume
22
Issue
sup1
Pages
22 - 32
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