Insulin Derived Fibrils Induce Cytotoxicity in vitro and Trigger Inflammation in Murine Models

Volume: 17, Issue: 1, Pages: 163 - 171
Published: Jul 21, 2021
Abstract
Effective exogenous insulin delivery is the cornerstone of insulin dependent diabetes mellitus management. Recent literature indicates that commercial insulin-induced tissue reaction and cellular cytotoxicity may contribute to variability in blood glucose as well as permanent loss of injection or infusion site architecture and function. It is well accepted that insulin formulations are susceptible to mechanical and chemical stresses that lead to...
Paper Details
Title
Insulin Derived Fibrils Induce Cytotoxicity in vitro and Trigger Inflammation in Murine Models
Published Date
Jul 21, 2021
Journal
Volume
17
Issue
1
Pages
163 - 171
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