Gene

Detector

Biotechnology

Biology

Biomedical engineering

Ablation

Cardiology

Pulse (music)

Electroporation

Biochemistry

In vivo

Physics

Collateral damage

Animal model

Optics

Criminology

Internal medicine

Sociology

Irreversible electroporation

Medicine

Chemistry

JACC. Clinical electrophysiology

This study compared monophasic 100-μs pulses with high-frequency electroporation (HF-EP) bursts using an in vivo animal model. Myocardial damage was evaluated by histologic analysis. Compared with 10 monophasic pulses, 20 bursts of HF-EP at 100 and 150 kHz were associated with less damage. However, when the number of HF-EP bursts was increased to 60, myocardial damage was comparable to that of the monophasic group. HF-EP protocols were associated with attenuated collateral muscle contractions. This study shows that HF-EP is feasible and effective and that pulse frequency has a significant effect on extent of ablation.

Comparing High-Frequency With Monophasic Electroporation Protocols in an In Vivo Beating Heart Model