Ligand (biochemistry)

Alpha-1A adrenergic receptor

G protein-coupled receptor

Receptor

Alpha-1D adrenergic receptor

Agonist

Biology

Endocrinology

Adrenergic

Beta-3 adrenergic receptor

Chemistry

Epinephrine

β2 adrenergic receptor

Adrenergic receptor

Cell biology

Alpha-1B adrenergic receptor

Biochemistry

Pharmacology

Biomolecules

Adrenergic receptors are G protein-coupled receptors for epinephrine and norepinephrine. They are targets of many drugs for various conditions, including treatment of hypertension, hypotension, and asthma. Adrenergic receptors are intensively studied in structural biology, displayed for binding poses of different types of ligands. Here, we summarized molecular mechanisms of ligand recognition and receptor activation exhibited by structure. We also reviewed recent advances in structure-based ligand discovery against adrenergic receptors.

Ligands of Adrenergic Receptors: A Structural Point of View