Global profiling of RNA-binding protein target sites by LACE-seq

Volume: 23, Issue: 6, Pages: 664 - 675
Published: Jun 1, 2021
Abstract
RNA-binding proteins (RBPs) have essential functions during germline and early embryo development. However, current methods are unable to identify the in vivo targets of a RBP in these low-abundance cells. Here, by coupling RBP-mediated reverse transcription termination with linear amplification of complementary DNA ends and sequencing, we present the LACE-seq method for identifying RBP-regulated RNA networks at or near the single-oocyte level....
Paper Details
Title
Global profiling of RNA-binding protein target sites by LACE-seq
Published Date
Jun 1, 2021
Volume
23
Issue
6
Pages
664 - 675
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