Mesenchymal stem cell

Tumor microenvironment

Cytokine

Biology

Cancer

Interleukin 6

Immunology

Oncostatin M

Glioma

Cell biology

Cancer research

Genetics

Immune system

Cancer cell

Cancer Cell

Hara et al. combine single-cell RNA sequencing and functional experiments to explore the crosstalk between glioblastoma and the microenvironment, revealing that macrophage-derived OSM induces the mesenchymal-like state of glioblastoma, a state associated with upregulation of major histocompatibility complex genes, and with potential implications for immunotherapy.

Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma