Internal medicine

Pathology

Pyroptosis

Liver injury

Alcoholic liver disease

Disease

Biology

Apoptosis

Immunology

Cirrhosis

Inflammation

Inflammasome

Steatohepatitis

Fatty liver

Programmed cell death

Cancer research

Biochemistry

Medicine

Immune system

Journal of Gastroenterology and Hepatology

Pyroptosis is a type of programmed cell death mediated by a multiprotein complex called the inflammasome through the pro-inflammatory activity of gasdermin D. This study aimed to recognize the final biological product that leads to pore formation in the cell membrane, lysis, pro-inflammatory cytokines release, and the establishment of an immune response. An exhaustive search engine investigation of an elevated immune response can induce a sustained inflammation that directly links this mechanism to non-alcoholic fatty liver disease and its progression to non-alcoholic steatohepatitis. Clinical studies and systematic reviews suggest that gasdermin D is a critical molecule between the immune response and the disease manifestation, which could be considered a therapeutic target for highly prevalent diseases characterized by presenting perpetuated inflammatory processes. Both basic and clinical research show evidence on the expression and regulation of the inflammasome-gasdermin D-pyroptosis trinomial for the progression of non-alcoholic fatty liver disease to non-alcoholic steatohepatitis.

Role of the inflammasome, gasdermin D, and pyroptosis in non‐alcoholic fatty liver disease