Messenger RNA

Myeloid cells

Methylation

Biology

Gene

N6-Methyladenosine

Chemistry

Myeloid leukemia

Myeloid

Cell biology

Cancer research

Biochemistry

Methyltransferase

Cancer Cell

Using AML cell lines and patient samples Cheng et al. identify a requirement for YTHDC1 in myeloid leukemogenesis. YTHDC1 undergoes liquid-liquid phase separation by binding to m6A to form dynamic nuclear condensates. These nuclear bodies are increased in myeloid leukemia cells and protect mRNAs from the PAXT-exosome complex.

N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation