Small molecule

Organic chemistry

Combinatorial chemistry

Piperazine

Stereochemistry

Chemistry

Moiety

Natural product

Antioxidant

Molecule

Biochemistry

Journal of Enzyme Inhibition and Medicinal Chemistry

Piperazine moiety is a cyclic molecule containing two nitrogen atoms in positions 1 and 4, as well as four carbon atoms. Piperazine is one of the most sought heterocyclics for the development of new drug candidates with a wide range of applications. Over 100 molecules with a broad range of bioactivities, including antitumor, antibacterial, anti-inflammatory, antioxidant, and other activities, were reviewed. This article reviewed investigations regarding piperazine groups for the modification of natural product derivatives in the last decade, highlighting parameters that affect their biological activity.

Piperazine skeleton in the structural modification of natural products: a review