Internal medicine

Enzyme

Gluconeogenesis

Diabetes mellitus

Biology

Endocrinology

Phosphoenolpyruvate carboxykinase

Chemistry

Hypoglycemia

Metabolism

Biochemistry

Medicine

Molecular Metabolism

Phosphoenolpyruvate carboxykinase (PCK) has been almost exclusively recognized as a critical enzyme in gluconeogenesis, especially in the liver and kidney. Accumulating evidence has shown that the enhanced activity of PCK leads to increased glucose output and exacerbation of diabetes, whereas the defects of PCK result in lethal hypoglycemia. Genetic mutations or polymorphisms are reported to be related to the onset and progression of diabetes in humans.

Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis