Clustering FunFams using sequence embeddings improves EC purity
Abstract
Classifying proteins into functional families can improve our understanding of protein function and can allow transferring annotations within one family. For this, functional families need to be 'pure', i.e., contain only proteins with identical function. Functional Families (FunFams) cluster proteins within CATH superfamilies into such groups of proteins sharing function. 11% of all FunFams (22 830 of 203 639) contain EC annotations and of...
Paper Details
Title
Clustering FunFams using sequence embeddings improves EC purity
Published Date
May 12, 2021
Journal
Volume
37
Issue
20
Pages
3449 - 3455
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