Internal medicine

Autophagy

Disease

Coronavirus disease 2019 (COVID-19)

Infectious disease (medical specialty)

Protein kinase B

Cancer

Apoptosis

Chemistry

Combination therapy

Hydroxychloroquine

Drug

Signal transduction

Cancer therapy

Cancer research

Biochemistry

Medicine

PI3K/AKT/mTOR pathway

Pharmacology

Journal of Materials Chemistry B

Abstract: In order to improve the effect of hydroxychloroquine (HCQ) on the selectivity in anti-tumour therapy, the α-linolenic acid conjugated hydroxychloroquine (AHQ) was designed, which was aiming to enhance anti-tumor...

Hydroxychloroquine based chemical drug for combination therapy with 5-Fu for inhibiting the pathway of Akt/mTOR in autophagy process on colon cancer