Four new highly oxidized sesquiterpene lactones from the leaves of Artemisia argyi

Four new highly oxidized sesquiterpene lactones, Argyoxynolides A–D, along with two known analogs were isolated from the leaves of Artemisia argyi H.Lév. & Vaniot. Their structures were characterized utilizing extensive spectroscopic methods. All isolates were evaluated for the LPS-induced nitric oxide (NO) production inhibitory activity and one compound exhibited activity with IC50 = 37.95 ± 4.39...