Artemisinin

Malaria

Biology

Nitric oxide

Artemisia annua

Botany

Plasmodium falciparum

Sesquiterpene lactone

Stereochemistry

Immunology

Artemisia

Organic chemistry

Sesquiterpene

Asteraceae

Medicine

Chemistry

Traditional medicine

Phytochemistry Letters

Four new highly oxidized sesquiterpene lactones, Argyoxynolides A–D, along with two known analogs were isolated from the leaves of Artemisia argyi H.Lév. & Vaniot. Their structures were characterized utilizing extensive spectroscopic methods. All isolates were evaluated for the LPS-induced nitric oxide (NO) production inhibitory activity and one compound exhibited activity with IC50 = 37.95 ± 4.39 μM.

Four new highly oxidized sesquiterpene lactones from the leaves of Artemisia argyi